Tompkinsville
- County:
- Monroe County
- County Seat:
- Yes
- Area (mi²):
- 3.284
- State:
- Kentucky
Tompkinsville is a city located in Monroe County, Kentucky. Tompkinsville has a 2026 population of 2,239. It is also the county seat of Monroe County. Tompkinsville is currently declining at a rate of -1.28% annually and its population has decreased by -2.57% since the most recent census, which recorded a population of 2,298 in 2020.