21 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Cambridge | Middlesex County | 124,928 |
| Chicopee | Hampden County | 55,449 |
| Chelsea | Suffolk County | 41,683 |
| Chelmsford | Middlesex County | 37,667 |
| Canton | Norfolk County | 25,887 |
| Concord | Middlesex County | 17,730 |
| Clinton | Worcester County | 15,950 |
| Charlton | Worcester County | 13,874 |
| Carver | Plymouth County | 11,997 |
| Cohasset | Norfolk County | 8,690 |
| Chatham | Barnstable County | 6,715 |
| Carlisle | Middlesex County | 5,455 |
| Cheshire | Berkshire County | 3,176 |
| Conway | Franklin County | 1,742 |
| Colrain | Franklin County | 1,673 |
| Clarksburg | Berkshire County | 1,627 |
| Chilmark | Dukes County | 1,273 |
| Chester | Hampden County | 1,233 |
| Charlemont | Franklin County | 1,177 |
| Chesterfield | Hampshire County | 1,164 |
| Cummington | Hampshire County | 811 |