Holyoke
- County:
- Hampden County
- County Seat:
- No
- Area (mi²):
- 21.169
- State:
- Massachusetts
Holyoke is a city located in Hampden County, Massachusetts. Holyoke has a 2026 population of 37,838. Holyoke is currently growing at a rate of 0.44% annually but its population has decreased by -0.79% since the most recent census, which recorded a population of 38,139 in 2020.