Mayersville is a city located in Issaquena County Mississippi. It is also the county seat of Issaquena County. With a 2020 population of 665, it is the 186th largest city in Mississippi and the 12096th largest city in the United States . Mayersville is currently growing at a rate of 5.89% annually and its population has increased by 21.57% since the most recent census, which recorded a population of 547 in 2010. Mayersville reached it's highest population of 665 in 2021. Spanning over 1 miles, Mayersville has a population density of 604 people per square mile.
The average household income in Mayersville is $21,717 with a poverty rate of 53.05%. The median rental costs in recent years comes to $244 per month, and the median house value is $130,900. The median age in Mayersville is 33.8 years, 33.3 years for males, and 53 years for females.