De Kalb
- County:
- Kemper County
- County Seat:
- Yes
- Area (mi²):
- 3.319
- State:
- Mississippi
De Kalb is a town located in Kemper County, Mississippi. De Kalb has a 2026 population of 832. It is also the county seat of Kemper County. De Kalb is currently declining at a rate of -0.72% annually and its population has decreased by -5.02% since the most recent census, which recorded a population of 876 in 2020.