
De Soto
- County:
- Clarke County
- County Seat:
- No
- Area (mi²):
- 3.781
- State:
- Mississippi
De Soto is a CDP located in Clarke County, Mississippi. De Soto has a 2025 population of 341. De Soto is currently growing at a rate of 7.23% annually and its population has increased by 30.65% since the most recent census, which recorded a population of 261 in 2020.
The average household income in De Soto is $37,167 with a poverty rate of 37.62%. The median age in De Soto is 32.8 years: 27.7 years for males, and 62.7 years for females.