Louisville
- County:
- Winston County
- County Seat:
- Yes
- Area (mi²):
- 15.098
- State:
- Mississippi
Louisville is a city located in Winston County, Mississippi. Louisville has a 2026 population of 5,899. It is also the county seat of Winston County. Louisville is currently declining at a rate of -0.71% annually and its population has decreased by -2.69% since the most recent census, which recorded a population of 6,062 in 2020.