4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Rolling Fork | 1 | 1,378 | 1,853 | -6.45% | 976 | 1 | City |
| Anguilla | 2 | 462 | 492 | -1.28% | 447 | 1 | Town |
| Cary | 3 | 221 | 239 | -1.78% | 313 | 1 | Town |
| Panther Burn | 4 | 86 | 103 | 7.5% | 134 | 1 | CDP |
Rolling Fork is the largest city in Sharkey County, with a population of 1,378.
Panther Burn is the smallest city in Sharkey County, with a population of 86.
There are 4 cities in Sharkey County, Mississippi.