Smithville
- County:
- Monroe County
- County Seat:
- No
- Area (mi²):
- 1.484
- State:
- Mississippi
Smithville is a town located in Monroe County, Mississippi. Smithville has a 2026 population of 506. Smithville is currently declining at a rate of -0.98% annually and its population has decreased by -0.78% since the most recent census, which recorded a population of 510 in 2020.