Cairo
- County:
- Randolph County
- County Seat:
- No
- Area (mi²):
- 0.3
- State:
- Missouri
Cairo is a village located in Randolph County, Missouri. Cairo has a 2026 population of 201. Cairo is currently declining at a rate of -0.99% annually and its population has decreased by -1.47% since the most recent census, which recorded a population of 204 in 2020.