Centerville
- County:
- Reynolds County
- County Seat:
- Yes
- Area (mi²):
- 0.319
- State:
- Missouri
Centerville is a city located in Reynolds County, Missouri. Centerville has a 2026 population of 163. It is also the county seat of Reynolds County. Centerville is currently declining at a rate of -0.61% annually and its population has decreased by -2.4% since the most recent census, which recorded a population of 167 in 2020.