
Charleston
- County:
- Mississippi County
- County Seat:
- Yes
- Area (mi²):
- 4.796
- State:
- Missouri
Charleston is a city located in Mississippi County, Missouri. Charleston has a 2025 population of 4,397. It is also the county seat of .Charleston is currently declining at a rate of -0.97% annually and its population has decreased by -4.64% since the most recent census, which recorded a population of 4,611 in 2020.
The average household income in Charleston is $51,448 with a poverty rate of 31.43%. The median age in Charleston is 42.9 years: 42.6 years for males, and 43.1 years for females.