
De Soto
- County:
- Jefferson County
- County Seat:
- No
- Area (mi²):
- 4.382
- State:
- Missouri
De Soto is a city located in Jefferson County, Missouri. De Soto has a 2025 population of 6,525. De Soto is currently growing at a rate of 0.25% annually and its population has increased by 1.24% since the most recent census, which recorded a population of 6,445 in 2020.
The average household income in De Soto is $54,855 with a poverty rate of 14.71%. The median age in De Soto is 32.6 years: 28.8 years for males, and 35.9 years for females.