
Doe Run
- County:
- St. Francois County
- County Seat:
- No
- Area (mi²):
- 2.41
- State:
- Missouri
Doe Run is a CDP located in St. Francois County, Missouri. Doe Run has a 2025 population of 759. Doe Run is currently declining at a rate of -1.3% annually but its population has increased by 15.53% since the most recent census, which recorded a population of 657 in 2020.
The average household income in Doe Run is $74,879 with a poverty rate of 22.45%. The median age in Doe Run is 53.3 years: 61.1 years for males, and 52.4 years for females.