Jefferson City
- County:
- Cole County
- County Seat:
- Yes
- Area (mi²):
- 36.06
- State:
- Missouri
Jefferson City is a city located in Cole County, Missouri. Jefferson City has a 2026 population of 42,564. It is also the county seat of Cole County. Jefferson City is currently declining at a rate of -0.02% annually but its population has increased by 0.08% since the most recent census, which recorded a population of 42,528 in 2020.