Keytesville
- County:
- Chariton County
- County Seat:
- Yes
- Area (mi²):
- 0.769
- State:
- Missouri
Keytesville is a city located in Chariton County, Missouri. Keytesville has a 2026 population of 447. It is also the county seat of Chariton County. Keytesville is currently declining at a rate of 0% annually and its population has increased by 0.22% since the most recent census, which recorded a population of 446 in 2020.