
Osceola
- County:
- St. Clair County
- County Seat:
- Yes
- Area (mi²):
- 1.079
- State:
- Missouri
Osceola is a city located in St. Clair County, Missouri. Osceola has a 2025 population of 995. It is also the county seat of .Osceola is currently growing at a rate of 1.22% annually and its population has increased by 6.42% since the most recent census, which recorded a population of 935 in 2020.
The average household income in Osceola is $44,004 with a poverty rate of 30.37%. The median age in Osceola is 43.6 years: 37.4 years for males, and 50 years for females.