Prairie Home
- County:
- Cooper County
- County Seat:
- No
- Area (mi²):
- 0.388
- State:
- Missouri
Prairie Home is a city located in Cooper County, Missouri. Prairie Home has a 2026 population of 266. Prairie Home is currently growing at a rate of 1.14% annually and its population has increased by 1.53% since the most recent census, which recorded a population of 262 in 2020.