Upper Sandusky is a city located in Wyandot County, Ohio. Upper Sandusky has a 2026 population of 6,627. It is also the county seat of Wyandot County. Upper Sandusky is currently declining at a rate of -0.29% annually and its population has decreased by -0.93% since the most recent census, which recorded a population of 6,689 in 2020.