Carlisle
- County:
- Cumberland County
- County Seat:
- Yes
- Area (mi²):
- 5.533
- State:
- Pennsylvania
Carlisle is a borough located in Cumberland County, Pennsylvania. Carlisle has a 2026 population of 22,517. It is also the county seat of Cumberland County. Carlisle is currently growing at a rate of 0.5% annually and its population has increased by 11.75% since the most recent census, which recorded a population of 20,149 in 2020.