Hartsville
- County:
- Darlington County
- County Seat:
- No
- Area (mi²):
- 5.99
- State:
- South Carolina
Hartsville is a city located in Darlington County, South Carolina. Hartsville has a 2026 population of 7,360. Hartsville is currently declining at a rate of -0.41% annually and its population has decreased by -1.05% since the most recent census, which recorded a population of 7,438 in 2020.