Simpsonville
- County:
- Greenville County
- County Seat:
- No
- Area (mi²):
- 9.713
- State:
- South Carolina
Simpsonville is a city located in Greenville County, South Carolina. Simpsonville has a 2026 population of 28,078. Simpsonville is currently growing at a rate of 1.71% annually and its population has increased by 18.95% since the most recent census, which recorded a population of 23,605 in 2020.