Irene
- County:
- Clay County
- County Seat:
- No
- Area (mi²):
- 0.255
- State:
- South Dakota
Irene is a city located in Clay County, South Dakota. Irene has a 2026 population of 431. Irene is currently declining at a rate of -0.69% annually but its population has increased by 1.17% since the most recent census, which recorded a population of 426 in 2020.