St. Lawrence
- County:
- Hand County
- County Seat:
- No
- Area (mi²):
- 0.343
- State:
- South Dakota
St. Lawrence is a town located in Hand County, South Dakota. St. Lawrence has a 2026 population of 161. St. Lawrence is currently declining at a rate of -1.23% annually and its population has decreased by -2.42% since the most recent census, which recorded a population of 165 in 2020.