South San Francisco is a city located in California. With a 2020 population of 68,133, it is the 130th largest city in California and the 547th largest city in the United States. South San Francisco is currently growing at a rate of 0.25% annually and its population has increased by 7.07% since the most recent census, which recorded a population of 63,632 in 2010. South San Francisco reached it's highest population of 68,133 in 2021. Spanning over 30 miles, South San Francisco has a population density of 7,385 people per square mile.
The average household income in South San Francisco is $129,305 with a poverty rate of 6.91%. The median rental costs in recent years comes to $2,105 per month, and the median house value is $844,000. The median age in South San Francisco is 40.4 years, 39.1 years for males, and 41.8 years for females. For every 100 females there are 96.6 males.