Port Isabel
- County:
- Cameron County
- County Seat:
- No
- Area (mi²):
- 18.271
- State:
- Texas
Port Isabel is a city located in Cameron County, Texas. Port Isabel has a 2026 population of 5,210. Port Isabel is currently growing at a rate of 1.36% annually and its population has increased by 3.78% since the most recent census, which recorded a population of 5,020 in 2020.