La Serena-Coquimbo's 2021 population is now estimated at 493,767. In 1950, the population of La Serena-Coquimbo was 63,886. La Serena-Coquimbo has grown by 10,127 since 2015, which represents a 2.09% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects. These estimates represent the Urban agglomeration of La Serena-Coquimbo, which typically includes La Serena-Coquimbo's population in addition to adjacent suburban areas.