| City | State | 2026 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Atlanta | Georgia | 534,278 | 0.98% | 1 | City |
| New Orleans | Louisiana | 357,183 | -1.37% | 2 | City |
| Huntsville | Alabama | 237,140 | 1.5% | 3 | City |
| Baton Rouge | Louisiana | 221,663 | -0.51% | 4 | City |
| Augusta | Georgia | 201,980 | -0.01% | 5 | Township |
| Columbus | Georgia | 200,935 | -0.61% | 6 | City |
| Mobile | Alabama | 199,605 | -0.61% | 7 | City |
| Birmingham | Alabama | 195,033 | -0.44% | 8 | City |
| Montgomery | Alabama | 194,258 | -0.53% | 9 | City |
| Shreveport | Louisiana | 173,439 | -1.4% | 10 | City |
| Charleston | South Carolina | 161,314 | 1.19% | 11 | City |
| Macon-Bibb County | Georgia | 157,632 | 0.05% | 12 | Township |
| Savannah | Georgia | 150,080 | 0.43% | 13 | City |
| Columbia | South Carolina | 149,103 | 1.41% | 14 | City |
| Metairie | Louisiana | 139,114 | 0.03% | 15 | CDP |
| Jackson | Mississippi | 138,450 | -1.94% | 16 | City |
| North Charleston | South Carolina | 131,980 | 2.12% | 17 | City |
| Athens | Georgia | 129,148 | 0.42% | 18 | Township |
| Lafayette | Louisiana | 123,618 | 0.25% | 19 | City |
| Tuscaloosa | Alabama | 116,477 | 1.89% | 20 | City |
| South Fulton | Georgia | 113,789 | 0.86% | 21 | City |
| Sandy Springs | Georgia | 104,328 | -0.65% | 22 | City |
| Mount Pleasant | South Carolina | 96,654 | 1.24% | 23 | Town |
| Hoover | Alabama | 93,661 | 0.12% | 24 | City |
| Roswell | Georgia | 91,308 | -0.22% | 25 | City |
| Warner Robins | Georgia | 89,165 | 1.6% | 26 | City |
| Auburn | Alabama | 86,786 | 1.97% | 27 | City |
| Lake Charles | Louisiana | 81,816 | -1.04% | 28 | City |
| Johns Creek | Georgia | 79,995 | -0.5% | 29 | City |
| Mableton | Georgia | 79,174 | 83.2% | 30 | City |
| Mableton | Georgia | 79,174 | 0.45% | 31 | City |
| Gulfport | Mississippi | 77,003 | 0.65% | 32 | City |
| Rock Hill | South Carolina | 76,202 | 0.38% | 33 | City |
| Greenville | South Carolina | 76,180 | 1.16% | 34 | City |
| Dothan | Alabama | 72,242 | 0.25% | 35 | City |
| Madison | Alabama | 69,611 | 2.42% | 36 | City |
| Alpharetta | Georgia | 67,211 | 0.43% | 37 | City |
| Albany | Georgia | 66,376 | -0.79% | 38 | City |
| Kenner | Louisiana | 64,911 | -0.35% | 39 | City |
| Marietta | Georgia | 64,152 | 0.91% | 40 | City |
| Bossier City | Louisiana | 63,398 | 0.22% | 41 | City |
| Stonecrest | Georgia | 61,847 | 0.83% | 42 | City |
| Brookhaven | Georgia | 60,343 | 1.17% | 43 | City |
| Southaven | Mississippi | 58,551 | 1.27% | 44 | City |
| Decatur | Alabama | 58,291 | 0.4% | 45 | City |
| Smyrna | Georgia | 57,798 | 0.5% | 46 | City |
| Valdosta | Georgia | 56,287 | 0.18% | 47 | City |
| Summerville | South Carolina | 53,623 | 0.84% | 48 | Town |
| Goose Creek | South Carolina | 53,108 | 2.11% | 49 | City |
| Greer | South Carolina | 52,676 | 5.34% | 50 | City |
| Dunwoody | Georgia | 51,870 | 0.15% | 51 | City |
| Gainesville | Georgia | 50,700 | 3% | 52 | City |
For this list, the Deep South Region is defined as the 5 states of Alabama, Georgia, Louisiana, Mississippi and South Carolina.