46 cities
| City | State | 2025 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Seattle | Washington | 791,093 | 1.29% | 1 | City |
| Portland | Oregon | 631,394 | -0.69% | 2 | City |
| Boise City | Idaho | 238,443 | 0.2% | 3 | City |
| Spokane | Washington | 230,960 | 0.15% | 4 | City |
| Tacoma | Washington | 230,313 | 0.93% | 5 | City |
| Vancouver | Washington | 200,919 | 0.97% | 6 | City |
| Salem | Oregon | 181,513 | 0.61% | 7 | City |
| Eugene | Oregon | 178,873 | 0.05% | 8 | City |
| Bellevue | Washington | 155,024 | 0.42% | 9 | City |
| Meridian | Idaho | 144,801 | 3.62% | 10 | City |
| Kent | Washington | 136,586 | 0% | 11 | City |
| Nampa | Idaho | 121,330 | 3.39% | 12 | City |
| Everett | Washington | 113,540 | 0.47% | 13 | City |
| Hillsboro | Oregon | 111,150 | 0.74% | 14 | City |
| Gresham | Oregon | 110,761 | -0.67% | 15 | City |
| Spokane Valley | Washington | 109,422 | 1.07% | 16 | City |
| Bend | Oregon | 108,735 | 1.69% | 17 | City |
| Renton | Washington | 105,245 | -0.28% | 18 | City |
| Federal Way | Washington | 100,066 | -0.19% | 19 | City |
| Beaverton | Oregon | 98,488 | 0.19% | 20 | City |
| Yakima | Washington | 97,466 | 0.08% | 21 | City |
| Bellingham | Washington | 96,857 | 1.04% | 22 | City |
| Kirkland | Washington | 96,188 | 0.72% | 23 | City |
| Kennewick | Washington | 87,410 | 0.79% | 24 | City |
| Medford | Oregon | 86,293 | -0.01% | 25 | City |
| Auburn | Washington | 85,130 | -0.45% | 26 | City |
| Redmond | Washington | 84,400 | 2.68% | 27 | City |
| Pasco | Washington | 82,733 | 1.23% | 28 | City |
| Marysville | Washington | 77,516 | 1.72% | 29 | City |
| Caldwell | Idaho | 76,174 | 4.22% | 30 | City |
| Idaho Falls | Idaho | 70,421 | 1.29% | 31 | City |
| Shoreline | Washington | 68,108 | 2.8% | 32 | City |
| Sammamish | Washington | 66,230 | -0.37% | 33 | City |
| Richland | Washington | 65,242 | 1.35% | 34 | City |
| Corvallis | Oregon | 62,905 | 1.47% | 35 | City |
| Lakewood | Washington | 62,481 | -0.36% | 36 | City |
| Springfield | Oregon | 61,011 | -0.28% | 37 | City |
| Lacey | Washington | 59,114 | 0.8% | 38 | City |
| Pocatello | Idaho | 58,680 | 0.77% | 39 | City |
| Coeur d'Alene | Idaho | 57,955 | 1.05% | 40 | City |
| Tigard | Oregon | 57,867 | 0.99% | 41 | City |
| Albany | Oregon | 57,313 | 0.27% | 42 | City |
| Twin Falls | Idaho | 56,457 | 1.56% | 43 | City |
| Olympia | Washington | 56,436 | 0.29% | 44 | City |
| Bothell | Washington | 52,669 | 1.74% | 45 | City |
| Burien | Washington | 52,058 | 0.02% | 46 | City |
For this list, the Pacific Northwest Region is defined as the 3 states of Idaho, Oregon and Washington.