Jeffersonville
- County:
- Twiggs County
- County Seat:
- Yes
- Area (mi²):
- 3.655
- State:
- Georgia
Jeffersonville is a city located in Twiggs County, Georgia. Jeffersonville has a 2026 population of 926. It is also the county seat of Twiggs County. Jeffersonville is currently declining at a rate of -0.32% annually and its population has decreased by -4.93% since the most recent census, which recorded a population of 974 in 2020.