Kalamazoo is a city located in Kalamazoo County, Michigan. Kalamazoo has a 2026 population of 73,290. It is also the county seat of Kalamazoo County. Kalamazoo is currently declining at a rate of -0.13% annually and its population has decreased by -0.27% since the most recent census, which recorded a population of 73,489 in 2020.