
Chillicothe
- County:
- Ross County
- County Seat:
- Yes
- Area (mi²):
- 10.5
- State:
- Ohio
Chillicothe is a city located in Ross County, Ohio. Chillicothe has a 2025 population of 21,799. It is also the county seat of .Chillicothe is currently declining at a rate of -0.22% annually and its population has decreased by -1.08% since the most recent census, which recorded a population of 22,038 in 2020.
The average household income in Chillicothe is $69,691 with a poverty rate of 20.07%. The median age in Chillicothe is 41.7 years: 37.8 years for males, and 46.6 years for females.