Waynesburg
- County:
- Greene County
- County Seat:
- Yes
- Area (mi²):
- 0.805
- State:
- Pennsylvania
Waynesburg is a borough located in Greene County, Pennsylvania. Waynesburg has a 2026 population of 3,701. It is also the county seat of Greene County. Waynesburg is currently declining at a rate of -1.31% annually and its population has decreased by -7.29% since the most recent census, which recorded a population of 3,992 in 2020.