18 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Aiken | Aiken County | 32,962 |
| Anderson | Anderson County | 31,676 |
| Abbeville | Abbeville County | 4,876 |
| Arthurtown | Richland County | 3,770 |
| Arkwright | Spartanburg County | 3,582 |
| Arcadia | Spartanburg County | 2,745 |
| Andrews | Georgetown County | 2,500 |
| Allendale | Allendale County | 2,403 |
| Arial | Pickens County | 1,904 |
| Awendaw | Charleston County | 1,503 |
| Aynor | Horry County | 1,102 |
| Arcadia Lakes | Richland County | 851 |
| Atlantic Beach | Horry County | 527 |
| Adams Run | Charleston County | 455 |
| Alcolu | Clarendon County | 425 |
| Antreville | Abbeville County | 279 |
| Abney Crossroads | Kershaw County | 257 |
| Ashwood | Kershaw County | 43 |