18 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Dentsville | Richland County | 15,601 |
| Dillon | Dillon County | 6,178 |
| Darlington | Darlington County | 6,008 |
| Duncan | Spartanburg County | 4,725 |
| Dunean | Greenville County | 3,723 |
| Denmark | Bamberg County | 3,047 |
| Dalzell | Sumter County | 2,932 |
| Due West | Abbeville County | 1,307 |
| Drayton | Spartanburg County | 1,203 |
| Dovesville | Darlington County | 1,170 |
| Dunbar | Georgetown County | 865 |
| DeBordieu Colony | Georgetown County | 863 |
| Daufuskie Island | Beaufort County | 734 |
| Dale | Beaufort County | 718 |
| Danwood | Florence County | 443 |
| Donalds | Abbeville County | 324 |
| Daviston | Marion County | 303 |
| Dacusville | Pickens County | 249 |