18 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Dentsville | Richland County | 15,704 |
| Dillon | Dillon County | 6,113 |
| Darlington | Darlington County | 5,972 |
| Duncan | Spartanburg County | 4,856 |
| Dunean | Greenville County | 3,726 |
| Denmark | Bamberg County | 3,022 |
| Dalzell | Sumter County | 2,924 |
| Due West | Abbeville County | 1,322 |
| Drayton | Spartanburg County | 1,284 |
| Dovesville | Darlington County | 1,248 |
| Dunbar | Georgetown County | 923 |
| DeBordieu Colony | Georgetown County | 921 |
| Daufuskie Island | Beaufort County | 783 |
| Dale | Beaufort County | 766 |
| Danwood | Florence County | 473 |
| Donalds | Abbeville County | 325 |
| Daviston | Marion County | 324 |
| Dacusville | Pickens County | 266 |