19 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Easley | Pickens County | 28,984 |
| East Camden | Kershaw County | 5,182 |
| Edgefield | Edgefield County | 4,265 |
| East Gaffney | Cherokee County | 3,188 |
| Edisto | Orangeburg County | 2,192 |
| Elgin | Kershaw County | 2,177 |
| Eureka Mill | Chester County | 1,791 |
| Estill | Hampton County | 1,749 |
| Elgin | Kershaw County | 1,669 |
| Edmund | Lexington County | 1,568 |
| Edisto Beach | Charleston County | 1,076 |
| East Sumter | Lee County | 739 |
| Eastover | Richland County | 634 |
| Elloree | Orangeburg County | 538 |
| Ehrhardt | Bamberg County | 428 |
| Elliott | Lee County | 427 |
| Enoree | Spartanburg County | 427 |
| Eutawville | Orangeburg County | 242 |
| Elko | Barnwell County | 140 |