19 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Easley | Pickens County | 27,992 |
| East Camden | Kershaw County | 4,858 |
| Edgefield | Edgefield County | 4,206 |
| East Gaffney | Cherokee County | 3,182 |
| Edisto | Orangeburg County | 2,215 |
| Elgin | Kershaw County | 2,204 |
| Eureka Mill | Chester County | 1,771 |
| Estill | Hampton County | 1,759 |
| Elgin | Kershaw County | 1,663 |
| Edmund | Lexington County | 1,470 |
| Edisto Beach | Charleston County | 1,068 |
| East Sumter | Lee County | 776 |
| Eastover | Richland County | 631 |
| Elloree | Orangeburg County | 543 |
| Enoree | Spartanburg County | 442 |
| Ehrhardt | Bamberg County | 432 |
| Elliott | Lee County | 400 |
| Eutawville | Orangeburg County | 241 |
| Elko | Barnwell County | 140 |