18 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Fort Mill | Lancaster County | 41,764 |
| Florence | Florence County | 41,336 |
| Five Forks | Greenville County | 20,236 |
| Fountain Inn | Greenville County | 15,423 |
| Forest Acres | Richland County | 10,346 |
| Forestbrook | Horry County | 8,105 |
| Folly Beach | Charleston County | 2,088 |
| Fairforest | Spartanburg County | 1,715 |
| Fairfax | Allendale County | 1,340 |
| Fort Lawn | Chester County | 988 |
| Fripp Island | Beaufort County | 927 |
| Fairview Crossroads | Lexington County | 644 |
| Fair Play | Oconee County | 553 |
| Finklea | Horry County | 497 |
| Floydale | Dillon County | 290 |
| Fingerville | Spartanburg County | 262 |
| Furman | Hampton County | 222 |
| Foreston | Clarendon County | 81 |