8 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Irmo | Richland County | 12,234 |
| Isle of Palms | Charleston County | 4,384 |
| India Hook | York County | 3,866 |
| Inman | Spartanburg County | 3,442 |
| Irwin | Lancaster County | 1,862 |
| Iva | Anderson County | 1,206 |
| Inman Mills | Spartanburg County | 872 |
| Islandton | Colleton County | 62 |