
Mayesville
- County:
- Sumter County
- County Seat:
- No
- Area (mi²):
- 1.024
- State:
- South Carolina
Mayesville is a town located in Sumter County, South Carolina. Mayesville has a 2025 population of 539. Mayesville is currently declining at a rate of -0.37% annually and its population has decreased by -2.18% since the most recent census, which recorded a population of 551 in 2020.
The average household income in Mayesville is $49,014 with a poverty rate of 38.45%. The median age in Mayesville is 36.2 years: 37.1 years for males, and 27.3 years for females.