Chamberlain
- County:
- Brule County
- County Seat:
- No
- Area (mi²):
- 19.982
- State:
- South Dakota
Chamberlain is located in Brule County, South Dakota. Chamberlain has a 2025 population of 236 . Chamberlain is currently declining at a rate of -2.07% annually and its population has decreased by -0.42% since the most recent census, which recorded a population of 237 in 2020.
The median age in Chamberlain is 52.3 years: 0 years for males, and 52.8 years for females. For every 100 females there are 10.1 males.