Santa Ana's 2026 population is now estimated at 12,593. In 2000, the population of Santa Ana was 21,098. Santa Ana experienced a decrease of -294 residents over the past year, marking an annual decline of -2.28%. These population values and projections come from Panama census 2000 nomenclature places, Panama census 2010 nomenclature places, Panama census 2023 Cuadro 3 place population and World Population Review Internal Projections .