16 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Ellsworth | Hancock County | 8,884 |
| Eliot | York County | 7,568 |
| Eddington | Penobscot County | 2,274 |
| East Millinocket | Penobscot County | 1,563 |
| Enfield | Penobscot County | 1,442 |
| East Machias | Washington County | 1,327 |
| Easton | Aroostook County | 1,313 |
| Eastport | Washington County | 1,288 |
| Etna | Penobscot County | 1,237 |
| Edgecomb | Lincoln County | 1,215 |
| Exeter | Penobscot County | 996 |
| Embden | Somerset County | 962 |
| Eagle Lake | Aroostook County | 752 |
| Eustis | Franklin County | 680 |
| Eastbrook | Hancock County | 430 |
| Edinburg | Penobscot County | 133 |