25 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Mount Pleasant | Charleston County | 96,692 |
| Myrtle Beach | Horry County | 41,675 |
| Mauldin | Greenville County | 30,986 |
| Moncks Corner | Berkeley County | 19,588 |
| Murrells Inlet | Horry County | 10,478 |
| Marion | Marion County | 5,993 |
| Manning | Clarendon County | 3,813 |
| Mullins | Marion County | 3,805 |
| Mayo | Spartanburg County | 2,020 |
| McColl | Marlboro County | 1,953 |
| McCormick | Edgefield County | 1,894 |
| Monarch Mill | Union County | 1,831 |
| Meggett | Charleston County | 1,467 |
| Murphys Estates | Aiken County | 1,148 |
| Manville | Kershaw County | 937 |
| McBee | Chesterfield County | 818 |
| McClellanville | Charleston County | 631 |
| Modoc | McCormick County | 631 |
| Mayesville | Sumter County | 549 |
| Mount Carmel | McCormick County | 357 |
| McConnells | York County | 288 |
| Monetta | Aiken County | 209 |
| Mulberry | Sumter County | 184 |
| Mount Croghan | Chesterfield County | 135 |
| Mountville | Laurens County | 99 |