| City | County | 2026 Pop. ↓ |
|---|---|---|
| Mount Pleasant | Charleston County | 96,654 |
| Myrtle Beach | Horry County | 42,111 |
| Mauldin | Greenville County | 32,739 |
| Moncks Corner | Berkeley County | 21,875 |
| Murrells Inlet | Horry County | 10,673 |
| Marion | Marion County | 5,965 |
| Manning | Clarendon County | 3,814 |
| Mullins | Marion County | 3,805 |
| Mayo | Spartanburg County | 2,049 |
| McColl | Marlboro County | 1,953 |
| McCormick | Edgefield County | 1,947 |
| Monarch Mill | Union County | 1,832 |
| Meggett | Charleston County | 1,500 |
| Murphys Estates | Aiken County | 1,128 |
| Manville | Kershaw County | 999 |
| McBee | Chesterfield County | 826 |
| Modoc | McCormick County | 659 |
| McClellanville | Charleston County | 648 |
| Mayesville | Sumter County | 554 |
| Mount Carmel | McCormick County | 366 |
| McConnells | York County | 289 |
| Monetta | Aiken County | 214 |
| Mulberry | Sumter County | 161 |
| Mount Croghan | Chesterfield County | 139 |
| Mountville | Laurens County | 98 |