19 cities
| City | County | 2026 Pop. ↓ |
|---|---|---|
| Rock Hill | York County | 76,370 |
| Red Hill | Horry County | 17,232 |
| Red Bank | Lexington County | 11,258 |
| Roebuck | Spartanburg County | 3,761 |
| Ridgeland | Jasper County | 3,739 |
| Ravenel | Charleston County | 2,756 |
| Riverview | York County | 2,569 |
| Reidville | Spartanburg County | 1,943 |
| Ridgeville | Dorchester County | 934 |
| Ridge Spring | Saluda County | 594 |
| Ruby | Chesterfield County | 326 |
| Richburg | Chester County | 266 |
| Rowesville | Orangeburg County | 251 |
| Ridgeway | Fairfield County | 250 |
| Russellville | Berkeley County | 223 |
| Reevesville | Dorchester County | 194 |
| Rembert | Sumter County | 174 |
| Rockville | Charleston County | 143 |
| Rains | Marion County | 49 |