Prairie du Chien
- County:
- Crawford County
- County Seat:
- Yes
- Area (mi²):
- 5.901
- State:
- Wisconsin
Prairie du Chien is a city located in Crawford County, Wisconsin. Prairie du Chien has a 2026 population of 5,472. It is also the county seat of Crawford County. Prairie du Chien is currently declining at a rate of -0.31% annually and its population has decreased by -0.98% since the most recent census, which recorded a population of 5,526 in 2020.