Santa Ana's 2026 population is now estimated at 249,665. In 2007, the population of Santa Ana was 245,421. Santa Ana has grown by 123 in the last year, which represents a 0.05% annual change. These population values and projections come from DIGESTYC Censo de Poblacion y Vivienda 2007 poblacion por municipio and ONEC-DIGESTYC proyecciones municipales de poblacion 2020-2030 revision 2021 .