Santa Clara's 2026 population is now estimated at 6,247. In 2007, the population of Santa Clara was 5,349. Santa Clara has grown by 41 in the last year, which represents a 0.66% annual change. These population values and projections come from DIGESTYC Censo de Poblacion y Vivienda 2007 poblacion por municipio and ONEC-DIGESTYC proyecciones municipales de poblacion 2020-2030 revision 2021 .