Santo Domingo's 2026 population is now estimated at 6,926. In 2007, the population of Santo Domingo was 6,445. Santo Domingo has grown by 31 in the last year, which represents a 0.45% annual change. These population values and projections come from DIGESTYC Censo de Poblacion y Vivienda 2007 poblacion por municipio and ONEC-DIGESTYC proyecciones municipales de poblacion 2020-2030 revision 2021 .