Mekele's 2025 population is now estimated at 637,226. In 1950, the population of Mekele was 14,107. Mekele has grown by 25,652 in the last year, which represents a 4.19% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects . These estimates represent the Urban agglomeration of Mekele, which typically includes Mekele's population in addition to adjacent suburban areas.
| City | 2025 Pop. ↓ | Growth |
|---|---|---|
| Addis Ababa | 5,956,680 | |
| Dire Dawa | 507,101 | |
| Gondar | 450,244 | |
| Mek'ele | 215,546 | |
| Adama | 213,995 | |
| Bahir Dar | 168,899 | |
| Dese | 136,056 | |
| Hawassa | 133,097 | |
| Jimma | 128,306 | |
| Bishoftu | 104,215 | |
| Kombolcha | 93,605 | |
| Harar | 90,218 | |
| Sodo | 86,050 | |
| Shashemene | 85,871 | |
| Hosa'ina | 75,963 | |
| Arba Minch | 69,622 | |
| Adigrat | 65,000 | |
| Debre Mark'os | 59,920 | |
| Debre Birhan | 57,787 | |
| Jijiga | 56,821 | |
| Inda Silase | 50,078 | |
| Ziway | 49,416 | |
| Dila | 47,021 | |
| Hagere Hiywet | 43,920 | |
| Gambela | 42,366 | |
| Axum | 41,249 | |
| Waliso | 38,394 | |
| Yirga `Alem | 36,292 | |
| Mojo | 34,547 | |
| Goba | 34,369 | |
| Shakiso | 34,078 | |
| Felege Neway | 33,429 | |
| Areka | 33,150 | |
| Boditi | 32,997 | |
| Debre Tabor | 32,659 | |
| Jinka | 32,115 | |
| Gimbi | 31,809 | |
| Asbe Teferi | 30,772 | |
| Korem | 30,633 | |
| Asosa | 30,512 | |
| Butajira | 30,502 | |
| Metu | 29,648 | |
| Agaro | 28,268 | |
| Kibre Mengist | 27,854 | |
| Maych'ew | 27,186 | |
| Werota | 26,813 | |
| Dembi Dolo | 26,748 | |
| Dubti | 26,370 | |
| Fiche | 25,758 | |
| K'olito | 25,614 | |
| Mendi | 25,239 | |
| Debark' | 24,700 | |
| Tippi | 24,169 | |
| Kemise | 23,861 | |
| Asasa | 23,790 | |
| Genet | 23,753 | |
| Finote Selam | 23,463 | |
| Metahara | 23,403 | |
| Dodola | 23,116 | |
| Addiet Canna | 22,946 | |
| Adis Zemen | 22,522 | |
| Hagere Maryam | 22,105 | |
| Bure | 22,038 | |
| Robit | 20,679 | |
| Asaita | 20,342 | |
| Bedele | 20,293 | |
| Nejo | 20,166 | |
| Sebeta | 19,533 | |
| Bati | 19,260 | |
| Bonga | 18,973 | |
| Bako | 17,872 | |
| Yabelo | 17,819 | |
| Bedesa | 17,526 | |
| Wenji | 17,120 | |
| Ginir | 16,757 | |
| Gebre Guracha | 16,583 | |
| Bichena | 16,411 | |
| Gelemso | 16,065 | |
| Shambu | 15,354 | |
| Abomsa | 15,258 | |
| Mizan Teferi | 14,002 | |
| Wendo | 12,945 | |
| Huruta | 12,442 | |
| Hirna | 12,295 | |
| Dejen | 11,739 | |
| Dabat | 11,544 | |
| Awash | 11,415 | |
| Leku | 11,398 | |
| Gewane | 11,279 | |
| Lalibela | 11,152 | |
| Gidole | 10,736 | |
| Debre Werk' | 10,579 | |
| Tulu Bolo | 10,531 | |
| Sirre | 10,089 |
