Mekele's 2025 population is now estimated at 637,226. In 1950, the population of Mekele was 14,107. Mekele has grown by 25,652 in the last year, which represents a 4.19% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects . These estimates represent the Urban agglomeration of Mekele, which typically includes Mekele's population in addition to adjacent suburban areas.