Mekele's 2026 population is now estimated at 664,246. In 1950, the population of Mekele was 14,107. Mekele has grown by 27,020 in the last year, which represents a 4.24% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects . These estimates represent the Urban agglomeration of Mekele, which typically includes Mekele's population in addition to adjacent suburban areas.