San Lorenzo's 2025 population is now estimated at 545,076. In 1992, the population of San Lorenzo was 133,395. San Lorenzo has grown by 340,720 in the last year, which represents a 4.36% annual change.
| City | 2025 Pop. ↓ | Growth |
|---|---|---|
| Asuncion | 3,627,220 | |
| Ciudad del Este | 344,919 | |
| Lambare | 99,572 | |
| Fernando de la Mora | 95,072 | |
| Capiata | 83,773 | |
| Encarnacion | 56,261 | |
| Pedro Juan Caballero | 53,566 | |
| Mariano Roque Alonso | 39,289 | |
| Coronel Oviedo | 38,316 | |
| Caaguazu | 38,220 | |
| Concepcion | 35,276 | |
| Presidente Franco | 31,825 | |
| Villa Elisa | 29,796 | |
| Villarrica | 27,818 | |
| Nemby | 26,999 | |
| Limpio | 26,177 | |
| Caazapa | 23,996 | |
| Pilar | 19,121 | |
| San Juan Bautista | 16,593 | |
| Ita | 14,259 | |
| Itaugua | 13,910 | |
| Nueva Esperanza | 12,717 | |
| Caacupe | 12,382 | |
| Juan de Ayolas | 12,061 | |
| Villa Hayes | 11,859 | |
| Santa Rita | 11,823 | |
| Colonia General Alfredo Stroessner | 11,558 | |
| San Isidro de Curuguaty | 11,095 | |
| Horqueta | 10,531 | |
| Lima | 10,367 | |
| Piribebuy | 10,337 | |
| Paraguari | 10,079 |